Non-IgG therapeutic antibody are antibody-based therapies that differ from the traditional immunoglobulin G (IgG) class of antibodies. While IgG antibodies are the most common type used in therapeutic applications due to their stability, long half-life, and strong immune effector functions, non-IgG antibodies offer distinct structures and mechanisms that can provide alternative therapeutic benefits. Non-IgG antibodies include other immunoglobulin classes, such as IgA, IgM, IgE, and antibody-like scaffolds that do not follow the traditional Ig structure.